Life–threatening orolingual angioedema during thrombolysis in acute ischemic stroke

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Hemi Orolingual Angioedema after tPA Administration for Acute Ischemic Stroke

INTRODUCTION As studies continue to demonstrate the efficacy of intravenous tissue plasminogen activator (tPA) in acute ischemic stroke, the exclusion criteria continue to narrow, and the time-window continues to increase.1-3 The most dreaded adverse effect of tPA, hemorrhagic conversion of an ischemic stroke, is well known and well published.3 However, as an increasing number of patients are r...

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Raising awareness of orolingual angioedema as a complication of thrombolysis in acute stroke patients.

1 Sundt TM, Sharbrough FW, Piepgras DG, Kearns TP, Messick JM, O’Fallon WM: Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy. Mayo Clin Proc 1981; 56: 533–543. 2 van Mook W, Rennenberg R, Schurink G, et al: Cerebral hyperperfusion syndrome. Lancet Neurol 2005; 4: 877–888. 3 Russell DA, Gough MJ: Intracerebral haemorrhage following carotid enda...

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Orolingual Angioedema During or After Thrombolysis for Cerebral Ischemia.

BACKGROUND AND PURPOSE Orolingual angioedema (OLAE) is a life-threatening complication of intravenous thrombolysis. Our objective was to compare outcomes of patients with and without OLAE. METHODS We prospectively included consecutive patients who received intravenous thrombolysis for cerebral ischemia at Lille University Hospital. We examined tongue and lips every 15 minutes during thromboly...

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Thrombolysis in acute ischemic stroke.

The administration of rt-PA to patients with acute ischemic stroke can result in improved functional outcomes. The safe and effective use of rt-PA in routine medical practice requires that patients seek help early, have a well-defined onset of their symptoms, be carefully examined for contraindications to rt-PA, receive a CT scan and interpretation to exclude hemorrhage, and receive the drug wi...

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Orolingual and abdominal angioedema post thrombolysis and thrombectomy.

A 53-year-old man treated with an angiotensin-converting enzyme (ACE) inhibitor presented with left hemiplegia (NIH Stroke Scale 23). Magnetic resonance angiography revealed a right proximal middle cerebral artery occlusion (figure 1). Thirty minutes after thrombolysis, orolingual swelling was observed. Two hours later, just after mechanical thrombectomy was completed, he developed painful abdo...

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ژورنال

عنوان ژورنال: Journal of Neurology

سال: 2005

ISSN: 0340-5354,1432-1459

DOI: 10.1007/s00415-005-0789-9